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Youngjoo Kwon Selected Research

pyridine

12/2021Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
11/20214-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.
6/2017Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
5/2016A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
1/2016Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
10/2015Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
3/2010Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
1/20102-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
1/20102,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.

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Youngjoo Kwon Research Topics

Disease

60Neoplasms (Cancer)
03/2022 - 01/2007
13Breast Neoplasms (Breast Cancer)
06/2022 - 01/2007
6Ovarian Neoplasms (Ovarian Cancer)
02/2021 - 08/2010
5Colonic Neoplasms (Colon Cancer)
01/2017 - 01/2004
4Inflammation (Inflammations)
01/2020 - 05/2013
3Carcinogenesis
01/2022 - 01/2004
3Body Weight (Weight, Body)
07/2021 - 08/2009
3Lung Neoplasms (Lung Cancer)
04/2021 - 08/2016
3Fibrosis (Cirrhosis)
08/2020 - 12/2008
3Alzheimer Disease (Alzheimer's Disease)
01/2017 - 05/2012
3Aberrant Crypt Foci
01/2007 - 01/2004
2Adenocarcinoma
12/2021 - 07/2014
2Pulmonary Fibrosis (Fibrosing Alveolitis)
05/2021 - 06/2020
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2021 - 12/2017
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2017 - 01/2017
2Hypersensitivity (Allergy)
01/2012 - 06/2011
1Nervous System Diseases (Neurological Disorders)
02/2022
1Hypoxia (Hypoxemia)
01/2022
1Non-alcoholic Fatty Liver Disease
01/2022
1Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2021
1Prostatic Neoplasms (Prostate Cancer)
10/2021
1Abdominal Pain (Pain, Abdominal)
07/2021
1Premature Birth (Birth, Premature)
07/2021
1Ependymoma
06/2021
1Lung Diseases (Lung Disease)
05/2021
1COVID-19
05/2021
1Neoplasm Metastasis (Metastasis)
04/2021
1Triple Negative Breast Neoplasms
01/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2020
1Type 2 Diabetes Mellitus (MODY)
01/2020
1Insulin Resistance
01/2020
1Obesity
01/2020
1Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
12/2019

Drug/Important Bio-Agent (IBA)

18Type I DNA Topoisomerases (Topoisomerase I)IBA
03/2022 - 01/2010
15Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 01/2010
13trioctyl phosphine oxide (TOPO)IBA
12/2021 - 01/2015
9pyridineIBA
12/2021 - 01/2010
8Etoposide (VP 16)FDA LinkGeneric
06/2017 - 11/2013
7Type II DNA Topoisomerases (Topoisomerase II)IBA
10/2021 - 02/2010
7Biological ProductsIBA
12/2019 - 12/2009
6Doxorubicin (Adriamycin)FDA LinkGeneric
05/2018 - 01/2007
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2021 - 05/2013
4CurcuminIBA
08/2018 - 01/2004
4PyridinesIBA
01/2016 - 05/2010
3CalpainIBA
02/2022 - 04/2013
3HSP27 Heat-Shock ProteinsIBA
04/2021 - 08/2016
3Proteins (Proteins, Gene)FDA Link
01/2017 - 07/2010
3DNA (Deoxyribonucleic Acid)IBA
02/2015 - 02/2010
3Peptides (Polypeptides)IBA
04/2013 - 06/2011
2Estrogen ReceptorsIBA
06/2022 - 11/2014
2Pharmaceutical PreparationsIBA
04/2021 - 08/2010
2Cisplatin (Platino)FDA LinkGeneric
04/2021 - 10/2017
2Mitogen-Activated Protein KinasesIBA
02/2021 - 01/2017
2CytokinesIBA
02/2021 - 01/2016
2Bleomycin (Blenoxane)FDA LinkGeneric
08/2020 - 06/2020
2PoisonsIBA
12/2019 - 01/2018
2ResveratrolIBA
08/2018 - 12/2008
2sulforaphaneIBA
08/2018 - 01/2017
2EnzymesIBA
04/2018 - 10/2016
2CamptothecinIBA
06/2017 - 07/2014
2Amyloid (Amyloid Fibrils)IBA
01/2017 - 04/2013
2Neuroprotective AgentsIBA
10/2016 - 04/2013
2Blood Glucose (Blood Sugar)IBA
04/2016 - 08/2009
2Hydroxyl RadicalIBA
07/2015 - 05/2010
2TamoxifenFDA LinkGeneric
11/2014 - 10/2013
2LigandsIBA
09/2014 - 05/2013
2Conjugated Linoleic AcidsIBA
04/2013 - 12/2008
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
06/2007 - 01/2007
2AzoxymethaneIBA
01/2007 - 01/2006
1bisphenol AIBA
06/2022
1CalciumIBA
02/2022
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022
1EstersIBA
01/2022
1AcidsIBA
01/2022
1Transcription Factors (Transcription Factor)IBA
01/2022
1Androgen Receptors (Androgen Receptor)IBA
10/2021
1AndrogensIBA
10/2021
1Capsaicin (Zostrix)FDA Link
07/2021
1RetinoidsIBA
07/2021
1AngiotensinsIBA
05/2021
1zerumboneIBA
04/2021
1Gefitinib (Iressa)FDA Link
04/2021
1Serum-Free Culture MediaIBA
02/2021
1Conditioned Culture MediaIBA
02/2021
1Acetylcysteine (Siran)FDA LinkGeneric
01/2021
1Acetyl Coenzyme A (Acetyl-CoA)IBA
08/2020
1human ERBB2 proteinIBA
06/2020
1Trastuzumab (Herceptin)FDA Link
06/2020
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
06/2020
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
06/2020
1plumbaginIBA
06/2020
1protectin D1IBA
01/2020
1Docosahexaenoic AcidsIBA
01/2020
1Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2020
1Eicosapentaenoic AcidIBA
01/2020
1Nonesterified Fatty Acids (NEFA)IBA
12/2019
1lauric acid (dodecanoic acid)IBA
12/2019

Therapy/Procedure

13Therapeutics
10/2021 - 08/2010
7Drug Therapy (Chemotherapy)
03/2022 - 06/2007
1Castration
10/2021